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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MDH2
All Species:
42.73
Human Site:
T290
Identified Species:
72.31
UniProt:
P40926
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P40926
NP_005909.2
338
35503
T290
T
E
C
T
Y
F
S
T
P
L
L
L
G
K
K
Chimpanzee
Pan troglodytes
XP_001156205
338
35499
T290
T
E
C
T
Y
F
S
T
P
L
L
L
G
K
K
Rhesus Macaque
Macaca mulatta
XP_001114888
374
39932
T326
T
E
C
T
Y
F
S
T
P
L
L
L
G
K
K
Dog
Lupus familis
XP_849944
338
35431
T290
A
D
C
A
Y
F
S
T
P
L
L
L
G
K
K
Cat
Felis silvestris
Mouse
Mus musculus
P08249
338
35593
T290
T
E
C
T
Y
F
S
T
P
L
L
L
G
K
K
Rat
Rattus norvegicus
P04636
338
35665
T290
T
E
C
T
Y
F
S
T
P
L
L
L
G
K
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_415765
351
36949
T303
T
E
S
P
Y
F
S
T
P
L
L
L
G
K
N
Frog
Xenopus laevis
NP_001085326
338
35691
T290
T
E
S
P
Y
F
S
T
P
L
L
L
G
K
N
Zebra Danio
Brachydanio rerio
NP_998296
337
35401
T289
T
E
C
K
Y
F
S
T
P
L
L
L
G
K
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650696
336
35299
T290
T
E
A
T
F
F
S
T
P
L
V
L
G
K
N
Honey Bee
Apis mellifera
XP_392478
338
35783
A293
D
T
K
Y
F
S
T
A
V
V
L
G
K
A
G
Nematode Worm
Caenorhab. elegans
O02640
341
35101
T294
K
G
V
E
Y
F
S
T
P
V
E
L
G
P
N
Sea Urchin
Strong. purpuratus
XP_792004
337
35239
N292
T
E
S
S
Y
F
A
N
P
I
L
L
G
K
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SN86
403
42387
S348
T
D
L
P
F
F
A
S
R
V
K
I
G
K
N
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
85.8
93.1
N.A.
94.9
94.3
N.A.
N.A.
84.3
84
84.6
N.A.
58.8
65
56.8
68.3
Protein Similarity:
100
100
88.5
97
N.A.
98.2
97.9
N.A.
N.A.
91.1
92
93.1
N.A.
76.3
80.7
72.7
83.1
P-Site Identity:
100
100
100
80
N.A.
100
100
N.A.
N.A.
80
80
86.6
N.A.
73.3
6.6
46.6
60
P-Site Similarity:
100
100
100
86.6
N.A.
100
100
N.A.
N.A.
80
80
86.6
N.A.
86.6
26.6
53.3
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
50.6
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
63.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
66.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
8
8
0
0
15
8
0
0
0
0
0
8
0
% A
% Cys:
0
0
50
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
15
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
72
0
8
0
0
0
0
0
0
8
0
0
0
0
% E
% Phe:
0
0
0
0
22
93
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
8
0
0
0
0
0
0
0
0
0
8
93
0
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
8
0
8
0
0
0
% I
% Lys:
8
0
8
8
0
0
0
0
0
0
8
0
8
86
43
% K
% Leu:
0
0
8
0
0
0
0
0
0
72
79
86
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
50
% N
% Pro:
0
0
0
22
0
0
0
0
86
0
0
0
0
8
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% R
% Ser:
0
0
22
8
0
8
79
8
0
0
0
0
0
0
0
% S
% Thr:
79
8
0
43
0
0
8
79
0
0
0
0
0
0
0
% T
% Val:
0
0
8
0
0
0
0
0
8
22
8
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
79
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _